Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal

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СКАЧАТЬ size, (b) polydispersity index, and (c) zeta potential.

TABLE 2.6. Independent and Dependent (Response) Variables: Face‐Centered Central Composite Design (CCD) Scheme

Run	Type	Critical Process Parameters (CPPs, also Called as Independent Variables)	Critical Quality Attributes (CQAs, also Called as Dependent Variables)
Castor Oil (ml)	Chitosan (mg)	Poloxamer (mg)	MPS (nm)	PDI	ZP (mV)
1	Axial	2	12	87.5	676.4	0.655	27.6
2	Center	1.5	12	87.5	609.8	0.655	27.2
3	Factorial	1	18	75	247.6	0.376	24.6
4	Axial	1.5	12	75	396.4	0.275	35.5
5	Axial	1.5	18	87.5	449.4	0.661	29.1
6	Center	1.5	12	87.5	609.8	0.655	27.2
7	Factorial	2	6	100	417.1	0.62	17.1
8	Factorial	2	18	100	438.1	0.469	23.2
9	Factorial	2	6	75	390.5	0.438	28.5
10	Center	1.5	12	87.5	609.8	0.655	27.2
11	Axial	1.5	12	100	441.5	0.488	18.8
12	Axial	1	12	87.5	374.2	0.435	33.6
13	Axial	1.5	6	87.5	333.9	0.408	30.6
14	Center	1.5	12	87.5	609.8	0.655	27.2
15	Factorial	1	6	75	240.1	0.287	17.9
16	Factorial	1	6	100	447.6	0.676	15.6
17	Center	1.5	12	87.5	609.8	0.655	27.2
18	Factorial	1	18	100	453.4	0.62	25.1
19	Factorial	2	18	75	492.8	0.537	20.9
20	Center	1.5	12	87.5	609.8	0.655	27.2

      MPS, mean particle size; PDI, polydispersity index; ZP, zeta potential.

      Each row indicates an experiment while the columns present the composition and the critical quality attributes (CQAs) of the non‐phospholipid‐based topical ophthalmic emulsions.

The search for design space and optimized emulsion formula was carried out by numerical and graphical techniques using the software. The interaction effect of the CPPs on the CQAs was visualized using the response surfaces and 3D contour plots of the fitted polynomial regression СКАЧАТЬ