A History of Neuropsychology. Группа авторов

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СКАЧАТЬ position, reported finding “notably more” on the left (quoted in Bateman [53], p 380). He also found the left frontal lobe to be heavier ([54]). Asked whether F3 made the difference, he said he was inclined to this view but was reluctant to say more given the difficulty in surgically isolating this structure (reported in [55]).

Size was considered too. Cunningham [56] measured the upward angle of the Sylvian fissure’s posterior ramus in human fetuses. Finding it smaller on the left, he concluded that the region it bounded ventrally, containing the planum temporale, part of what by then was being called Wernicke’s area, was larger on that side. But seeing the same in great apes – animals with no known language – he questioned whether it is “in any way associated with … localization of the active speech centre …” (p 293). He presumably meant “comprehensioncentre.”

      What about the right hemisphere? For the temporal and occipital lobes, Gratiolet found earlier convolutional development on the right, the reverse of that for the frontal lobes. For the occipital lobe, Broca reported the same for number: “the right is richer in convolutions” (in [53] but, with his focus on speech, would have had no reason to see it as significant. Hughlings-Jackson [38] had very good reason: “These anatomical facts, I submit, support the view … that the hinder part of the brain on the right side, is the chief seat … in the recognition of objects, places, persons, &c.” (p 70).

      The Role of the Corpus Callosum

      By the 1920s, with the discovery and further documentation of lateral differences in function along with reports of possible clues to their anatomical origins, cerebral specialization had become a bedrock principle of neuropsychology, although the terms “major” and “minor” persisted, implying that left-hemisphere functions were still seen as more important.

The discovery rekindled the interest in an old question about the corpus callosum. Before Broca, it was regarded as a bridge between functionally symmetrical hemispheres. Thus Gall [57], recognizing that each pair of organs must be “united for mutual influence and the attainment of a common end,” named the “transverse layers of fibers (commissures)” as the link (p 600). This was a major advancement from the still older view of Vesalius [58] that its role was purely mechanical: to connect the two halves of the brain, thereby “preserv(ing) the patency of the ventricular cavities and support(ing) the fornix” (p 578; for review, see Harris [59].

      In the new era of cerebral specialization, the corpus callosum could be seen as connecting functionally asymmetric hemispheres, allowing their differences to merge in the service of mind. The new era also raised new questions: What if a lesion destroyed the left visual cortex and the splenium of the corpus callosum, preventing information sent to the right visual cortex from reaching the angular gyrus of the left hemisphere? Or, after research showed a region of cortex to be motorically excitable, what if an anterior callosal lesion prevented a verbal command to use the left hand from reaching that region of the right hemisphere? It was these questions that inspired analyses of disorders of reading (Dejerine [35]) and praxis (Liepmann [37]).

      Further Developments

Since the 1950s, and at an accelerating pace, have come ever deeper analyses of cerebral specialization stemming from advances in virtually every facet of neuropsychological science: the development and adoption of standardized tests of the aphasias, agnosias, and other neuro-cognitive as well as neuro-affective disorders; the incorporation of theory and research in cognitive science, including the study of memory, perception, attention, problem-solving, and executive control; large-scale studies, many of war veterans, comparing left- and right-hemisphere injuries; and, using such new electrophysiological and imaging methods as ERP, PET, MRI, fMRI, MEG, and SPECT, vast improvements in measuring structure and function in clinical and non-clinical populations, and with DTI (diffusion tensor imaging), in providing new details on connectivity through in vivo delineation of white-matter tracts. Along with these advances have come studies of the development of cerebral specialization; of the corpus callosum and the effects of its surgical separation; of the effects of side, time, and type of injury on function; and of the relation between cerebral specialization and a host of variables, including sex, handedness (degree as well as direction), intelligence, culture, literacy, and special talents and disabilities. Still other studies are focusing on cerebral specialization in other species; its embryological, anatomical, hormonal, genetic, and evolutionary foundations; and, ultimately, its benefits for the individual and the species. The outcome is that much progress has been made and many lessons learned. To name just a few examples: Broca was correct: a “small number” of persons do “speak with the right hemisphere,” and there is indeed no necessary coincidence between them and left-handers, the majority of whom, like nearly all right-handers, speak with the left (Harris [60]); Broca’s region, however, is found to have a broader range of language-related functions than speech-production [61]. Developmental studies also reveal hemispheric differences in motor and cognitive functions in infancy and even well before birth (e.g., [62, 63]), and methods such as DTI are revealing promising clues to the origins of cerebral specialization in the form of hemispheric differences in macro- and microscopic structural organization (e.g., [62]; see also [64]). New research also suggests an important benefit of a lateralized brain: greater processing efficiency [65], which makes more understandable why cerebral specialization is increasingly found to be a species-wide characteristic in vertebrates [66] as well as invertebrates [67]. Along with these examples, more general descriptions of cerebral specialization are being sought; one sees the left as specialized for well-learned action sequences, the right for detecting and responding to unexpected, behaviorally relevant stimuli in the environment [68]. And as a last and especially telling example, “faculties” are no longer regarded as complete in themselves and wholly lateralized to either side. Consider language and music: as noted by Patel [69], although languages have nouns and verbs, grammatical categories with no analogues in music, they have other features in common and are served by both hemispheres, each taking the lead for certain ones. As summarized by Peretz et al. [70], the left leads for pitch (tone) intervals, rhythm and timing (temporal order), sequencing, and perception of duration; the right for tonal patterns, melody, timbre, and emotion. And instead of modularity, with each feature, or function, uniquely associated with an anatomically distinct region, they are organized into cortical as well as sub-cortical neural networks (a so-called distributive-processing model), some working in parallel, others overlapping. Progress has not СКАЧАТЬ