Gas Biology Research in Clinical Practice. Группа авторов

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СКАЧАТЬ Biology as well as by Research and Development of the Next-Generation Integrated Simulation of Living Matter, a part of the Development and Use of the Next-Generation Supercomputer Project of MEXT.

      References

1 Tenhunen R, Marver HS, Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968;61:748-755.

2 Goda N, Suzuki K, Naito M, Takeoka S, Tsuchida E, Ishimura Y, Tamatani T, Suematsu M: Distribution of heme oxygenase isoforms in rat liver: topographic basis for carbon monoxide-mediated microvascular relaxation. J Clin Invest 1998;101:604-612.

3 Makino N, Suematsu M, Sugiura Y, Morikawa H, Shiomi S, Goda N, Sano T, Nimura Y, Sugimachi K, Ishimura Y: Altered expression of heme oxygenase-1 in the livers of patients with portal hypertensive diseases. Hepatology 2001;33:32-42.

4 Kovtunovych G, Eckhaus MA, Ghosh MC, Ollivierre-Wilson H, Rouault TA: Dysfunction of the heme recycling system in heme oxygenase-1 deficient mice: effects on macrophage viability and tissue iron distribution. Blood 2010 Oct 1. [Epub ahead of print]

5 Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S: Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 1999;103:129-135.

6 Suematsu M, Kashiwagi S, Sano T, Goda N, Shinoda Y, Ishimura Y: Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem Biophys Res Commun 1994;205:1333-1337.

7 Suematsu M, Goda N, Sano T, Kashiwagi S, Egawa T, Shinoda Y, Ishimura Y: Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest 1995;96:2431-2437.

8 Mori M, Suematsu M, Kyokane T, Sano T, Suzuki H, Yamaguchi T, Ishimura Y, Ishii H: Carbon monoxide-mediated alterations in paracellular permeability and vesicular transport in acetaminophen-treated perfused rat liver. Hepatology 1999;30:160-168.

9 Kyokane T, Norimizu S, Taniai H, Yamaguchi T, Takeoka S, Tsuchida E, Naito M, Nimura Y, Ishimura Y, Suematsu M: Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver. Gastroenterology 2001;120:1227-1240.

10 Wakabayashi Y, Takamiya R, Mizuki A, Kyokane T, Goda N, Yamaguchi T, Takeoka S, Suematsu M, Ishimura Y: Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver. Am J Physiol Gastrointest Liver Physiol 1999;277:G1088-G1096.

11 Bautista AP, Spitzer JJ: Inhibition of nitric oxide formation in vivo enhances superoxide release by the perfused liver. Am J Physiol 1994;266:G783-G788.

12 Kharitonov VG, Sharma VS, Pilz RB, Magde D, Koesling D: Basis of guanylate cyclase activation by carbon monoxide. Proc Natl Acad Sci USA 1995; 92:2568-2571.

13 Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka T, Soga T: Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem 2006;281:16768-16776.

14 Shintani T, Iwabuchi T, Soga T, Kato Y, Yamamoto T, Takano N, Hishiki T, Ueno Y, Ikeda S, Sakuragawa T, Ishikawa K, Goda N, Kitagawa Y, Kajimura M, Matsumoto K, Suematsu M: Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology 2009;49:141-150.

15 Taoka S, Banerjee R: Characterization of NO binding to human cystathionine β-synthase: possible implications of the effects of CO and NO binding to the human enzyme. J Inorg Biochem 2001;87:245-251.

      Makoto Suematsu, MD

      Department of Biochemistry, School of Medicine, Keio University

      35 Shinanomachi, Shinjuku-ku

      Tokyo 160-8582 (Japan)

       Tel. +81 3 5363 3753, Fax +81 3 5363 3466, E- Mail [email protected]

       General

      Yoshikawa T, Naito Y (eds): Gas Biology Research in Clinical Practice.

       Basel, Karger, 2011, pp 6–14

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Intraluminal Gas and Gastrointestinal Diseases

      Yoshihisa Urita · Toshiyasu Watanabe · Ikutaka Takemoto · Yosuke Sasaki · Tadashi Maeda · Manabu Matsumoto · Yoshiko Honda · Nagato Shimada · Hitoshi Nakajima · Motonobu Sugimoto

      Department of General Medicine and Emergency Care, Toho University, School of Medicine, Tokyo, Japan

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      Abstract

      Gases are also produced while passing through the gastrointestinal tract, possibly resulting in abdominal symptoms although gas is continuously removed by eructation, anal evacuation, absorption through the intestinal mucosa, and bacterial consumption. It seems that 2–8 liters of air may be swallowed and eructated per day. Approximately 5–10 liters of CO₂ seems to be produced and released into the lumen by chemical reactions in the upper gut. The pCO₂ rises dramatically in the duodenum, resulting in diffusion of CO₂ from lumen to blood, whereas CO₂ in swallowed air diffuses from the blood into the stomach. The pN₂ of swallowed air is slightly higher than that of venous blood in the stomach, possibly resulting in very slow absorption. Since pH₂ and pCH₄ are always higher in the lumen than in the blood, gases are constantly diffusing from the lumen to the blood. The calculated amount of H₂ produced in the colon is 2.7–27 liters per day because H₂ gas is produced at a rate of 4 liters for every 12.5 g of undigested carbohydrate. Since CH₄ production occurs primarily in the left colon whereas H₂ is produced primarily in the right colon, H₂ produced in the left colon may be rapidly converted to CH₄, possibly resulting in reduced flatus. Greater amount of gases pass through the digestive tract per day than liquid and solid contents, suggesting that impaired gas movement might be more closely associated with abdominal symptoms compared to liquid movement.

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      The overall function of the digestive system is to transfer the СКАЧАТЬ