Introduction to the Human Cell. Danton PhD O'Day

Чтение книги онлайн.

СКАЧАТЬ in Breast Development

      Breast tissue is a secretory tissue designed for the storage and release of milk protein. Different types of connexin proteins are present in different regions of the developing breast indicating variations in the types of gap junctions that function in those regions (Figure 4.8). Focusing in on human breast duct in the following figure, note that Cx26 is expressed primarily in the duct luminal cells while Cx43 is localized in gap junctions in the contractile myoepithelial cells that regulate the release of the milk from the alveolus. Both of these gap junction proteins undergo developmental changes.

      Figure 4.8. Connexin expression in mammary gland duct cells in mouse and human. ECM = extracellular matrix.

      If Cx26 gene expression is knocked down in mice at puberty, alveolar development is impaired and lactation is prevented. If the Cx43 gene is knocked out the mice die at birth. A conditional knockout for Cx43 has not been generated. There is also evidence that in normal breast tissue both Cx26 and Cx43 have tumor suppressive roles.

      Конец ознакомительного фрагмента.

      Текст предоставлен ООО «ЛитРес».

      Прочитайте эту книгу целиком, купив полную легальную версию на ЛитРес.

      Безопасно оплатить книгу можно банковской картой Visa, MasterCard, Maestro, со счета мобильного телефона, с платежного терминала, в салоне МТС или Связной, через PayPal, WebMoney, Яндекс.Деньги, QIWI Кошелек, бонусными картами или другим удобным Вам способом.

/9j/4AAQSkZJRgABAQECWAJYAAD/2wBDAAMCAgMCAgMDAwMEAwMEBQgFBQQEBQoHBwYIDAoMDAsK CwsNDhIQDQ4RDgsLEBYQERMUFRUVDA8XGBYUGBIUFRT/2wBDAQMEBAUEBQkFBQkUDQsNFBQUFBQU FBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBQUFBT/wAARCATiA8UDASIA AhEBAxEB/8QAHgABAAICAgMBAAAAAAAAAAAAAAcIBgkEBQEDCgL/xABuEAABAwMCBAMEBQUHDA0H BREBAAIDBAUGBxEIEiExE0FRCRQiYRUyQnGBI1JikaEWMzhygrG0FyQ3Q3R1dpKisrPBGBklNDU2 U1ZXc5TR00Rjg5PC0vAmJ1RVlZaXw+RkhaPE1OEoOUVGR1jx/8QAHAEBAAIDAQEBAAAAAAAAAAAA AAUGAwQHAgEI/8QAQREAAgEDAgMF

СКАЧАТЬ