Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development. Mike Lee S.

Скачать книгу в различных форматах или читать онлайн на сайте.

Название: Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development

Автор: Mike Lee S.

Издательство: John Wiley & Sons Limited

Жанр: Медицина

Серия:

isbn: 9781118916940

isbn: 0

Аннотация:

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development