Prodrugs and Targeted Delivery. Towards Better ADME Properties. Hugo Kubinyi

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Название: Prodrugs and Targeted Delivery. Towards Better ADME Properties

Автор: Hugo Kubinyi

Издательство: John Wiley & Sons Limited

Жанр: Медицина

Серия:

isbn: 9783527633173

isbn: 0

Аннотация:

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.