The Emperor of All Maladies. Siddhartha Mukherjee

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СКАЧАТЬ as a professor in Berlin, Billroth launched a systematic study of methods to open the human abdomen to remove malignant masses. Until Billroth’s¹⁴⁶ time, the mortality following abdominal surgery had been forbidding. Billroth’s approach to the problem was meticulous and formal: for nearly a decade, he spent surgery after surgery simply opening and closing abdomens of animals and human cadavers, defining clear and safe routes to the inside. By the early 1880s, he had established the routes: “The course so far is already¹⁴⁵ sufficient proof that the operation is possible,” he wrote. “Our next care, and the subject of our next studies, must be to determine the indications, and to develop the technique to suit all kinds of cases. I hope we have taken another good step forward towards securing unfortunate people hitherto regarded as incurable.”

      At the Allgemeines Krankenhaus, the teaching hospital in Vienna where he was appointed a professor, Billroth and his students now began to master and use a variety of techniques to remove tumors from the stomach, colon, ovaries, and esophagus, hoping to cure the body of cancer. The switch from exploration to cure produced an unanticipated challenge. A cancer surgeon’s task was to remove malignant tissue while leaving normal tissues and organs intact. But this task, Billroth soon discovered, demanded a nearly godlike creative spirit.

      Since the time of Vesalius, surgery had been immersed in the study of natural anatomy. But cancer so often disobeyed and distorted natural anatomical boundaries that unnatural boundaries had to be invented to constrain it. To remove the distal end of a stomach filled with cancer, for instance, Billroth had to hook up the pouch remaining after surgery to a nearby piece of the small intestine. To remove the entire bottom half of the stomach, he had to attach the remainder to a piece of distant jejunum. By the mid-1890s, Billroth had operated on forty-one patients with gastric carcinoma using these novel anatomical reconfigurations. Nineteen of these patients had survived the surgery.

      These procedures represented pivotal advances in the treatment of cancer. By the early twentieth century, many locally restricted cancers (i.e., primary tumors without metastatic lesions) could be removed by surgery. These included uterine and ovarian cancer, breast and prostate cancer, colon cancer, and lung cancer. If these tumors were removed before they had invaded other organs, these operations produced cures in a significant fraction of patients.

      But despite these remarkable advances, some cancers—even seemingly locally restricted ones—still relapsed after surgery, prompting second and often third attempts to resect tumors. Surgeons returned to the operating table¹⁴⁷ and cut and cut again, as if caught in a cat-and-mouse game, as cancer was slowly excavated out of the human body piece by piece.

      But what if the whole of cancer could be uprooted at its earliest stage using the most definitive surgery conceivable? What if cancer, incurable by means of conventional local surgery, could be cured by a radical, aggressive operation that would dig out its roots so completely, so exhaustively, that no possible trace was left behind? In an era captivated by the potency and creativity of surgeons, the idea of a surgeon’s knife extracting cancer by its roots was imbued with promise and wonder. It would land on the already brittle and combustible world of oncology like a firecracker thrown into gunpowder.

       A Radical Idea

      The professor who blesses the occasion¹⁴⁸

      Which permits him to explain something profound

      Nears me and is pleased to direct me—

      “Amputate the breast.”

      “Pardon me,” I said with sadness

      “But I had forgotten the operation.”

      —Rodolfo Figuoeroa,

      —in Poet Physicians

      It is over¹⁴⁹: she is dressed, steps gently and decently down from the table, looks for James; then, turning to the surgeon and the students, she curtsies—and in a low, clear voice, begs their pardon if she has behaved ill. The students—all of us—wept like children; the surgeon happed her up.

      —John Brown describing a nineteenth-century mastectomy

      William Stewart Halsted¹⁵⁰, whose name was to be inseparably attached to the concept of “radical” surgery, did not ask for that distinction. Instead, it was handed to him almost without any asking, like a scalpel delivered wordlessly into the outstretched hand of a surgeon. Halsted didn’t invent radical surgery. He inherited the idea from his predecessors and brought it to its extreme and logical perfection—only to find it inextricably attached to his name.

      Halsted was born in 1852, the son of a well-to-do clothing merchant in New York. He finished high school at the Phillips Academy in Andover and attended Yale College, where his athletic prowess, rather than academic achievement, drew the attention of his teachers and mentors. He wandered into the world of surgery almost by accident, attending medical school not because he was driven to become a surgeon but because he could not imagine himself apprenticed as a merchant in his father’s business. In 1874, Halsted matriculated at the College of Physicians and Surgeons at Columbia. He was immediately fascinated by anatomy. This fascination, like many of Halsted’s other interests in his later years—purebred dogs, horses, starched tablecloths, linen shirts, Parisian leather shoes, and immaculate surgical sutures—soon grew into an obsessive quest. He swallowed textbooks of anatomy whole and, when the books were exhausted, moved on to real patients with an equally insatiable hunger.

      In the mid-1870s, Halsted passed an entrance examination to be a surgical intern at Bellevue, a New York City hospital swarming with surgical patients. He split his time between the medical school and the surgical clinic, traveling several miles across New York between Bellevue and Columbia. Understandably, by the time he had finished medical school, he had already suffered a nervous breakdown. He recuperated for a few weeks on Block Island, then, dusting himself off, resumed his studies with just as much energy and verve. This pattern—heroic, Olympian exertion to the brink of physical impossibility, often followed by a near collapse—was to become a hallmark of Halsted’s approach to nearly every challenge. It would leave an equally distinct mark on his approach to surgery, surgical education—and cancer.

      Halsted entered surgery at a transitional moment in its history. Bloodletting, cupping, leaching, and purging were common procedures. One woman with convulsions and fever from a postsurgical infection was treated with even more barbaric attempts at surgery: “I opened a large orifice¹⁵¹ in each arm,” her surgeon wrote with self-congratulatory enthusiasm in the 1850s, “and cut both temporal arteries and had her blood flowing freely from all at the same time, determined to bleed her until the convulsions ceased.” Another doctor, prescribing a remedy for lung cancer, wrote, “Small bleedings give temporary relief,¹⁵² although, of course, they cannot often be repeated.” At Bellevue, the “internes” ran about in corridors with “pus-pails,”¹⁵³ the bodily drippings of patients spilling out of them. Surgical sutures were made of catgut, sharpened with spit, and left to hang from incisions into the open air. Surgeons walked around with their scalpels dangling from their pockets. If a tool fell on the blood-soiled floor, it was dusted off and inserted back into the pocket—or into the body of the patient on the operating table.

      In October СКАЧАТЬ