Название: Hormone Replacement: How to Balance Your Hormones Naturally
Автор: Dr. Cabot Sandra
Издательство: HarperCollins
Жанр: Здоровье
isbn: 9780008104641
isbn:
What Can You Do If You Have Too Many Male Hormones?
If you have excessive amounts of male hormones (androgens) in your body, you may notice several things:
excess facial and body hair (hirsutism)
loss of scalp hair, especially in the male pattern of balding
greasy skin and/or pimples
difficulty losing weight, especially from the trunk and abdomen
The hormonal profile of a woman going through the menopause, and after the menopause, can vary greatly, and this is why blood and/or saliva tests are so useful, to pinpoint your individual hormonal profile. Some women will have elevated levels of androgens even many years after they go through the menopause. These androgens are produced from the fat in the upper body and abdomen, and also from the adrenal glands. Obviously women with elevated levels of their own natural androgens do not need to receive any testosterone therapy, and usually find that synthetic progestogens make their hormonal imbalance worse. This is because synthetic progestogens may exert a mild androgenic effect. Natural progesterone does not have any androgenic effects, and should be used in women with excess androgens who need HRT.
The blood test that is most accurate to detect raised levels of the androgens is called the Free Androgen Index (FAI). This measures the amount of active androgens, which are unbound to proteins and are thus free to exert their effect in the body. If your FAI level is elevated, it is definite that you have excessive male hormone activity in your body. If you do not have any troubling symptoms and are not overweight, then this is not really a problem and you do not need to worry about it; however very high levels of male hormones should always be investigated by a specialist endocrinologist.
I have found that many women with an elevated FAI have normal blood levels of total testosterone, and thus just by measuring total testosterone levels alone you cannot get an accurate diagnosis of androgen excess. You must ask your doctor to order a Free Androgen Index (FAI) test if you want an accurate diagnosis.
Strategies for Women with Symptoms of Excess Androgens
Weight loss from the upper body and abdomen will reduce the production of androgens from the fat tissue.
Creams or troches containing natural oestrogens and progesterone can reduce the dominance of the androgens, thus making the hormonal profile more feminine.
If the androgen excess is severe and is producing marked symptoms, the anti-male hormone called Cyproterone acetate can be prescribed. Cyproterone acetate comes in the form of 50-mg tablets. The dose of cyproterone can vary from 1/4 of a tablet (12.5 mg) to one tablet (50 mg) daily. Cyproterone also acts as a progestogen, and as such can be given along with oestrogen to balance the effect of oestrogen on the uterus. If cyproterone is given every day, then there will not be any bleeding; if you desire to have a regular period, then the cyproterone can be given cyclically, for 18 days of every calendar month, along with your oestrogen. You must avoid pregnancy while taking cyproterone acetate. Generally speaking cyproterone is well tolerated, especially if the dose is tailor-made to match the patient’s blood tests and the severity of her symptoms. If the correct dose is used, then cyproterone will reduce the action of the male hormones so that we achieve a big improvement in all the symptoms of excessive androgens. Interestingly, we find that in women whose obesity is associated with excess androgen levels, the use of cyproterone will aid weight loss. This is because high levels of androgens will aggravate the high insulin levels found in Syndrome X. Syndrome X is a chemical imbalance that makes your body store fat and prevents your body from burning fat. If too much cyproterone is given, the level of the body’s androgens will be reduced too much and the patient may complain of fatigue, depression and loss of libido. As with all forms of hormone therapy, it is vital to tailor-make the correct dose for each patient, and over time the dose may need further adjustment.
Testing for Hormonal Imbalances
When Can Hormone Tests Be Useful?
To determine if you are menopausal. Blood tests are better for this initial test, to check your FSH levels and baseline levels of total sex hormones.
During the pre-menopausal years, if you have heavy and/or painful menstrual bleeding, fibroids or irregular menstrual cycles, as this could indicate a progesterone deficiency. The best time to measure progesterone levels is seven days before your menstrual bleeding is due, although if your cycle has become irregular and/or infrequent, it can be difficult to pinpoint this exact time. Salivary and blood tests should be done to check progesterone levels.
If you are on hormone replacement therapy, to indicate if your response to treatment is adequate. These tests can be blood and/or saliva tests. The blood tests are done every three to six months; the saliva tests can be done more often. The tests are more necessary if you are on HRT and you still feel that your hormones are out of balance. For women on higher-dose forms of HRT, such as implants or injections, blood tests can be helpful to check that you are not receiving an excessive dosage. We do not want to produce very high blood levels of hormones that are above the normal ranges, so blood and saliva tests can check for over-dosing as well as under-dosing. If you are on HRT and feel well, you may not need any hormone tests at all.
Useful Blood Tests and their Normal Ranges During the Menopause
HORMONE | COMMENTS | NORMAL RANGE DURING THE MENOPAUSE |
Free testosterone | Measures the free component of testosterone, which is the active hormone. |
Blood: 0.5 to 6pmol/L
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