Large Animal Neurology. Joe Mayhew

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In summary, damage to the spinal cord at the level of a reflex arc at its final motor neuron will denervate the effector muscle, resulting in flaccid (loss of tone) paralysis with degrees of hypotonia and hyporeflexia at the level of the lesion. In contrast, a similar severe lesion cranial or rostral to a reflex arc will result in hypertonic (spastic) paralysis. The latter is characterized by loss of voluntary motor function as with a final motor neuron lesion, but the reflex is not diminished. Indeed, the reflex may be released from the calming influence of its controlling central motor pathways and be hyperactive with concomitant hypertonia (spasticity—sic.) or stiffness in body parts such as limbs. When a central motor pathway lesion causes a degree of spastic paralysis, the involvement of adjacent proprioceptive and nociceptive sensory pathways also results in ataxia and possibly hypalgesia, respectively.

      Certainly, the concept of considering motor activity on the basis of “upper” and “lower” motor neuron function and lesions, even for quadrupeds, is entrenched in veterinary neurology, although not without some comment.^3,5 Anatomically, upper and lower are not acceptable (with the exception of some cranial structures such as eyelids) as terms of direction in veterinary anatomy (Nomina Anatomica Veterinaria, 6th Edition),¹ making the use of these descriptors confusing to say the least. Also, in contrast to “upper” and “lower” motor function generators and pathways, the concept of central pattern generators has its merits when considering gait and posture in humans and animals.¹¹ In this model, there is a generator of highly developed skilled motor activity initiated, in primates, in the cerebrum. A further generator of motor function, most prominent in our large animals, resides in the midbrain and rostral medulla oblongata. Finally, there is a generator at the spinal level that can initiate reflex actions and indeed probably is responsible for primitive gait patterns (viz. “spinal walking”); the interested reader may find further reading on this concept quite intriguing.^12–15 For several reasons, therefore, there is a strong argument in veterinary anatomy and neurology to dispense with upper motor neuron (UMN) and lower motor neuron (LMN) terminologies: a strategy we have accepted for this text. The CNS pathways involved with initiating motor function and maintaining appropriate muscle tone and hence body posture are referred to as central motor pathways that directly influence the final motor neurons innervating muscle to effect all motor functions. Many final motor neuron somata reside in the brainstem and spinal cord of the CNS with axons in the PNS, the exceptions being the presynaptic final motor neurons of the autonomic nervous system (ANS) which are wholly in the periphery.

The cerebellum is the major coordinating center for voluntary movement (Figure 1.5). It synthesizes impulses received from the cerebral cortex, the brainstem motor centers, and spinocerebellar and vestibular (special) proprioceptive pathways. It then provides feedback impulses to the motor centers to coordinate all motor functions.

Figure 1.5 Important cerebellar connections include subconscious general proprioceptive input from the body such as via spinocerebellar pathways shown as D (same as A in Figure 1.4). Other input is received from cerebrocortical A and brainstem B motor areas and vestibular centers C. All cerebellar efferent output is from cerebellar cortical (Purkinje) neurons connecting to brainstem B and cerebrocortical A motor areas.

Cranial nerves (CNs), numbering I through XII, leave the forebrain and brainstem (Figure 1.6). Some are involved with specialized modalities such as smell (CN I), sight (CN II), and balance and hearing (CN VIII). Some innervate eyeball muscles (CNs III, IV, and VI), muscles of facial expression (CN VII), pharynx and larynx (CNs IX and X), and tongue (CN XII). Others are involved with reflex functions such as facial reflexes (CNs V and VII) and the gag reflex (CNs IX and X). These cranial final motor neurons have central motor pathways controlling them. A final motor neuron lesion at the level of a CN or its nucleus can paralyze the motor function of the CN. Alternatively, a lesion affecting the efferent central motor pathways that influence the final motor neuron can curtail such CN motor function. As with spinal reflexes, in the latter case the structure (e.g., face) shows variable hypertonic, spastic paralysis (e.g., grimacing), with intact or hyperactive reflexes.

Figure 1.6 Some cranial nerves are involved with specialized modalities such as smell CN‐I, vision CN‐II, and balance and hearing CN‐VIII. Others innervate extraocular muscles CNs‐III, IV, and VI, pharynx and larynx CNs‐IX and X, and tongue CN‐XII, while some are involved with reflex function such as facial reflexes CNs V‐VII, similar to spinal reflex arcs.

Consciousness or mental awareness must be maintained within the forebrain (Figure 1.7A) for neurologic functions to occur. Numerous sensory inputs, including light, sound, touch, gravity, and metabolic and endocrine factors, interact, usually on an area of the brainstem known as the reticular activating system (Figure 1.7B). This system, by relaying impulses to the forebrain and brainstem, maintains the state of awareness and activity.

Figure 1.7 A state of alertness or consciousness is maintained by the forebrain A and particularly the reticular activating center B. These regions receive input from many other regions of the nervous system and are interconnected.

The final concept of clinical neuroanatomy important in interpreting large animal neurologic examinations is that of the specialized areas of relatively well‐developed functional centers that exist in the forebrain, but having brainstem connections, as introduced in Figure 1.8. The frontal and prefrontal cerebral lobes (A) are involved with mentation and behavior, and with fine motor activity at least in primates. As in humans, the parietal lobes (B) integrate conscious proprioceptive and nociceptive input in the large animal species. Certainly, vision appears to require an intact occipital cortex (C). Control of normal learned behavior and perception of sound may be functions of the temporal lobes (D). The hypothalamus and its pituitary gland (E) help control autonomic and endocrine functions of the body, whereas the deeper, old part of the brain known as the limbic system (F) may be involved with innate behavioral patterns. Finally, the basal nuclei (G) do appear to have some motor control at least for cranial nerve function in horses. Irrespective of the regions of the cerebral cortex, large lesions can occur which in their stable state do not result in permanent disability; so‐called silent areas (e.g. Figure 2.5).

Figure 1.8 Functional regions of the forebrain include the frontal cortex A involved with mentation, behavior, and motor activity; СКАЧАТЬ