Spiro Compounds. Группа авторов
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Название: Spiro Compounds

Автор: Группа авторов

Издательство: John Wiley & Sons Limited

Жанр: Химия

Серия:

isbn: 9781119567653

isbn:

СКАЧАТЬ

      Source: Modified from Arai et al. [9].

      Later on, the authors extended the application of their catalytic system (using a different ligand) to the 1,3‐dipolar cycloaddition of azomethine ylides to 5‐alkylidene thiazolidine‐2,4‐diones for the synthesis of spirocyclic pyrrolidine‐thiazolidinediones [12].

Schematic illustration of a chemical reaction depicting copper-catalyzed asymmetric construction of dispiropyrrolidine skeletons via 1,3-dipolar cycloaddition between azomethine ylides and alpha-alkylidene succinimides.

      Source: Modified from Yang et al. [11].

      A weak positive nonlinear effect was observed between the enantiomeric excess of the product 36 and the chiral ligand 34. Hence, the authors suggest the presence of both monomeric and oligomeric catalytic species in the reaction medium, with the monomeric complex being more active. Subsequently, an asymmetric [3+2] cycloaddition of methyleneindolinones with nitrones was also reported by the same authors using the combination of chiral N,N′‐dioxide ligand and Co(BF4)2·H2O to synthesize spirooxindole derivatives in good yield and excellent diastereo‐ and enantiocontrol [14].

Schematic illustration of a chemical reaction depicting magnesium-catalyzed asymmetric [3+2] cycloaddition between methyleneindolinones and N,N′-cyclic azomethine imines. Schematic illustration of a chemical reaction depicting rhodium-catalyzed enantioselective [3+2] annulation to form spirocyclic sultams.

      Source: Modified from Pham and Cramer [15].

      Source: Modified from Ma et al. [16].